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Therapy I Pharmacology part 2

"Ozone peroxides" as second messenger molecules
As reactive oxygen compounds, membrane-associated „ozone peroxides“, could act as second messengers via cysteine residues and/or reduction through glutathion GSH in a less agressive way than the superoxide radicals -O-O- and H2O2, and take over regulation of the antioxidants, i.e. without SOD and catalase demand as in the oxidative stress processes of relevant pathological conditions.

Short-chain hydroxy-hydroperoxide with its low tendency to radical reactions could initiate the regulation of antioxidant protective mechanisms as redox signal e.g. via the nuclear factors NFkB in stress and inflammation processes via Nrf2 (Viebahn 2006; Gough 2009; León 1998).

H2O2 formed from ozone peroxides, as proposed by other authors (e.g. Bocci 2011), will probably not fulfil this function, as the H2O2 content is as a rule pathologically increased in the patients concerned, the corresponding signal transduction is insufficient and there is a deficit in antioxidant enzymes.

Overview: Pharmacology of Medical Ozone
The pharmacological effects of low dose medical ozone are well documented and published:

1. Improved oxygen release by activation of the RBC metabolism
2. Immunomodulation by activation of the immunocompetent cells
3. Regulation of cellular antioxidants